
吴欢生(1988.3—),男,汉族,博士,副教授,硕士研究生导师。江西省家禽产业技术体系疫病综合防控岗位专家、江西省杰出青年基金项目获得者、江西农业大学“未来之星”。先后担任中国畜牧兽医学会动物传染病学与禽病学分会理事、江西省家禽协会常务理事。Viruses, Poultry Science,Virology,Virology Journal等SCI杂志审稿人。先后主持国家自然科学基金2项,江西省自然基金4项,江西省教育厅项目1项。以第一作者或通讯作者先后发表学术论文20余篇,其中SCI收录22篇,A类学报2篇,北大中文核心2篇,申请国家发明专利4项,授权实用新型专利2项。邮箱:huanswu@jxau.edu.cn,联系电话:18458219873(微信同号)。
教学工作:主讲《动物有害生物检疫》、《兽医公共卫生学》、《兽医微生物学》等课程。
科研工作:主要研究方向为家禽免疫抑制病的致病机制以及防控技术。
一、教育经历
2012.09-2019.03 浙江大学,兽医学,农学博士
2008.09-2012.06 江西农业大学,动物医学,农学学士
二、工作经历
2019.06-2023.11 江西农业大学 讲 师
2023.12-至今,江西农业大学 副教授
三、代表性研究论文
(1) Zeng Q#, Chen Z#, Huang Y, Fu Q, Chen Z, Wu H*. SRPK1 facilitates IBDV replication by phosphorylating VP1 at S48. Int J Biol Macromol. 2025 Feb;291:139002. (中科院大类一区Top,IF=7.7,通讯作者)
(2) Xifeng Hu#, Zheng Chen, Xiangdong Wu, Zhen Ding, Yu Huang, Qiuling Fu, Zhen Chen, Huansheng Wu*. Phosphorylation of VP1 Mediated by CDK1-Cyclin B1 Facilitates Infectious Bursal Disease Virus Replication[J]. Journal of Virology, 2023, 97(1): 1-20. (中科院大类二区,病毒学Top,IF=5.4,通讯作者)
(3) Xifeng Hu#, Zheng Chen, Xiaomei Wang, Qiuling Fu, Zhen Chen, Yu Huang, Huansheng Wu*. PRMT5 facilitates infectious bursal disease virus replication through arginine methylation of VP1[J]. Journal of Virology, 2023, 98(2): 1-18. (中科院大类二区,病毒学Top,IF=5.4,通讯作者)
(4) Huansheng Wu#, Hui Yang#, Gang Ji, Tuyuan Zheng, Yina Zhang, Tingjuan Deng, Xiaojuan Zheng, Jiyong Zhou*, Boli Hu.SUMO1 Modification Facilitates Avibirnavirus Replication by Stabilizing Polymerase VP1[J]. Journal of Virology, 2019, 93(10): e02227-18. (中科院大类二区,病毒学Top,IF=5.1,第一作者)
(5) Huansheng Wu#, Liuyuan Shi, Yina Zhang, Xiran Peng, Tuyuan Zheng, Yahui Li, Boli Hu, Xiaojuan Zheng, Jiyong Zhou*. Ubiquitination Is Essential for Avibirnavirus Replication by Supporting VP1 Polymerase Activity[J]. Journal of Virology, 2019, 93(3): e01899-18. (中科院大类二区,病毒学Top,IF=5.1,第一作者)
(6) Zeng Q#, Cao J#, Xie F, Zhu L, Wu X, Hu X, Chen Z, Chen X, Li X, Chiang CM, Wu H*. CRISPR-Cas9-mediated chicken prmt5 gene knockout and its critical role in interferon regulation. Poult Sci. 2024 Mar;103(3):103344. (中科院大类一区, IF=4.4,通讯作者)
(7) Wang K#, Huang M, Zeng Q, Wu H*. Characterization and functional analysis of chicken hnRNP protein. Poult Sci. 2025 Jan 28;104(3):104859. (中科院大类一区, IF=3.8,通讯作者)
(8) Xiong Z#, Cao J#, Wang K, Yang Y, Hu Y, Nie J, Zeng Q, Hu Y, Zhu L, Li X, Wu H*. Characterization and functional analysis of chicken CDK protein. Poult Sci. 2024 Jul;103(7):103833. (中科院大类一区, IF=3.8,通讯作者)
(9) Xiong Z#, Cao J#, Xiu M, Li A, Li X, Zhang Y, Zeng Q, Hu Y, Yang Y, Wu H*. Chicken PRMT3 facilitates IBDV replication. Poult Sci. 2024 Sep;103(9):103989. (中科院大类一区, IF=3.8,通讯作者)
(10) Xiong Z#, Zeng Q#, Hu Y, Lai C, Wu H*. Optineurin inhibits IBDV replication via interacting with VP1. Vet Microbiol. 2024 Nov;298:110261. (中科院大类二区, IF=2.4,通讯作者)
(11) Zheng Chen#, Xifeng Hu#, Xiangdong Wu, Yu Li, Zhen Ding, Qinghua Zeng, Tong Wan, Jingyi Yin, Huansheng Wu*. Development and Primary Application of an Indirect ELISA Based on Rep Protein to Analyze Antibodies against Porcine Cocirvirus-like Virus (PCLV) [J]. Viruses-Basel, 2022,1398): 1-10. (中科院大类二区, IF=5.8,通讯作者)
(12) Xifeng Hu#, Zheng Chen#, Xiangdong Wu, Zhen Ding, Qinghua Zeng, Huansheng Wu*. An Improved, Dual-Direction,Promoter-Driven, Reverse Genetics System for the Infectious Bursal Disease Virus (IBDV) [J]. Viruses-Basel, 2022,14(1396): 2-13. (中科院大类二区, IF=5.8,通讯作者)
(13) Xifeng Hu#, Huansheng Wu*. SUMOylation of optineurin is critical for inhibiting interferon b production[J]. Biochemical and Biophysical Research Communications, 2022, 07(44): 1-7. (中科院大类三区, IF=3.5,通讯作者)
(16) Xifeng Hu#, Zheng Chen, Yu Li, Zhen Ding, Qinghua Zeng, Tong Wan, Huansheng Wu*. Detection of Porcine Circovirus 1/2/3 and Genetic Analysis of Porcine Circovirus 2 in Wild Boar from Jiangxi Province of China [J]. Animals, 2022, 12(2021):1-11. (中科院大类二区, IF=3.2,通讯作者)
(15) Huansheng Wu*, Chengyao Hou*, Zhiru Wang, Puyan Meng, Hongying Chen, Huabin Cao First complete genomic sequence analysis of porcine circovirus type 4 (PCV4) in wild boars [J]. Veterinary Microbiology, 2022, 273(109547): 1-6. (中科院大类二区, IF=3.2,通讯作者)
(16) Xifeng Hu#, Xiangdong Wu, Meijia Xue, Yiting Chen, Beiyi Zhou, Tong Wan, Hongnan You, Huansheng Wu*. Chicken TAX1BP1 suppresses type I interferon production via degrading chicken MAVS and facilitates infectious bursal diseases virus replication[J]. Developmental and Comparative Immunology,2022, 135(104490): 1-8. (中科院大类二区, IF=3.6,通讯作者)
(17) Yu Li#, Ning Jinag, Yaqing Mao, Wenbo Zhang, Jing Xiao, Xiangdong Wu#, Huansheng Wu*. Chicken optineurin suppresses MDA5-mediated interferon β production[J]. Poultry Science, 2020, 10(1): 9-11. (中科院大类二区, IF=2.6,通讯作者)
(18) Xifeng Hu#, Xiangdong Wu, Zhen Ding. Zhen Cheng, Huansheng Wu*. Characterization and functional analysis of chicken dsRNA binding protein hnRNPU[J]. Developmental and comparative immunology, 2022, 148(104510):1-10. (中科院大类二区, IF=3.6,通讯作者)
(19) Xifeng Hu#, Zheng Chen, Deping Song, Yu Li, Zhen Ding, Xiangdong Wu, Hongnan You, Huansheng Wu*. Frequency detection of porcine circovirus-like virus in pigs with porcine respiratory disease[J]. Veterinary Microbiology, 2022, 275(109581):1-11. (中科院大类二区, IF=3.2,通讯作者)
(20) Xifeng Hu#, Zhen Ding, Yu Li, Zheng Chen, Huansheng Wu*. Serum investigations of antibodies against porcine circovirus 4 Rep and Cap protein in Jiangxi Province, China[J]. Frontiers in Microbiology, 2022, 12(34):1-9. (中科院大类二区, IF=6.06,通讯作者)
(21) Wang K#, Hu Y, Nie J, Zeng Q, Hu Y, Wu H. Chicken hnRNPK suppresses interferon production, thereby enhancing IBDV replication. Res Vet Sci. 2025 Mar;184:105527. (中科院大类三区, IF=2.2,通讯作者)
(22) Xifeng Hu, Xiangdong Wu, Zheng Chen, Huansheng Wu*. Chicken PRMT1 promotes infectious bursal disease virus replication via suppressing IFN-β production[J]. Developmental and Comparative Immunology,2023, 141(104628): 1-12. (中科院大类二区, IF=3.6,通讯作者)
(23) 吴欢生*, 康冬柳, 胡爱明, 刘远超, 李家奎, 瞿明仁, 欧阳克惠, 曹华斌. 江西省急性腹泻牛源的BHoV JX株全基因组序列测定及其分析[J].中国预防兽医学报, 2021.43(07): 772-776. (A类学报,第一作者)
(24) 吴欢生*, 康冬柳, 胡爱明, 刘远超, 李家奎, 瞿明仁, 欧阳克惠, 曹华斌. 野猪源猪圆环病毒4 型的发现及其Cap 基因序列分析[J].中国预防兽医学报, 2022.44(10): 1106-1110. (A类学报,第一作者)
(25) 胡颖,雷祖建,聂江江,等.猪圆环病毒4型在犬肾脏的检出及Rep基因序列分析[J].动物医学进展,2025,46(02):42-46. (北大中文核心,通讯作者)
(26) 聂江江,雷祖建,吴虹瑾,等.一例牛冠状病毒引起犊牛急性腹泻的分子生物学诊断与治疗[J].黑龙江畜牧兽医,2024,(20):81-85+128. (北大中文核心,通讯作者)
四、主持科研项目
[1] 国家自然科学基金面上项目:磷酸酶PP2A-B56α去磷酸化核糖核蛋白(RNP)抑制IBDV复制的分子机制(32373010),2024.01-2027.12,50万,主持,在研;
[2] 国家自然科学基金青年项目:解析周期蛋白依赖性激酶CDK1 磷酸化传染性法氏囊炎病(IBDV)VP1 蛋白的分子机制(32002288),2021.01-2023.12,30万,主持,结题;
[3] 江西省现代农业产业体系,家禽疫病综合控制岗位专家,2025.01-2027.12,90万,主持,在研。
[4] 江西省自然科学基金重点项目:IBDV核糖核蛋白(RNP)去磷酸化修饰机制研究(20232ACB205015),2023.07-2026.06,20万,主持,在研;
[5] 江西省自然科学基金杰出青年基金:Ubc9磷酸化促进IBDV复制机制研究(20242BAB23069),2026.06-2027.05,20万,主持,在研;
[6] 江西省自然科学基金项目:选择性自噬受体optineurin 靶向VP1 抑制传染性法氏囊炎病毒复制机制研究(90191087907),2020.12-2022.12,6万,主持,结题;
[7] 江西省教育厅科技计划项目:TAX1BP1 促进禽双RNA 病毒复制机制研究(GJJ190213),2019.12-2021.12,3万,主持,结题。
五、申请或授权国家专利
(1)吴欢生,邬向东,胡西风;基于CRISPR-Cas9敲除PRMT1基因DF-1细胞株的构建及其应用,发明专利,申请。
(2)吴欢生,邬向东,游洪南,胡西风;PRMT5基因敲除DF-1细胞株的构建及其应用,发明专利,申请。
(3)吴欢生,胡西凤,李钰,张昊;一种畜牧兽医专用连续灌药器,实用新型,授权。
(4)吴欢生,李钰,胡西凤,王旺林;一种兽医用夹持装置,实用新型,授权。